World’s biggest Covid 19 drug trial begins in UK – Burning Issues – Free PDF Download

• UK is doing World largest trial for COVID-19

About RECOVERY Trial

• The study is being conducted by the University of Oxford, which act as the sponsor for the research, working with doctors at many hospitals across the UK.
• Nearly 5876 patients at 169 active sites are participating under the trials. Procedure To Be Followed In A Trial

Recovery Trial…..Why????

• There are no drugs of proven value against COVID-19 although there are several which may turn out to be helpful (or possibly harmful) when added to the usual standard of care.
• This study aims to find out whether any of these additional treatments are of any help.
• The RECOVERY Trial will begin by testing some of these suggested treatments: ,

HydroxyCholoroquine

• HCQ is used to treat lupus and rheumatoid arthritis. It’s also used to prevent and treat malaria.
• The French study followed work by Chinese researchers which suggested that HCQ can slow infections from Sars-CoV-2 by blocking it from entering cells in the body.
• But there is no data showing the benefit of the medicine. Hence the drug is under RECOVERY trial.

Azithromycin

• Azithromycin is used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.
• Some Journals are recommending the combination of two.

Lopinavir-Ritonavir

• This combination product contains two medications: lopinavir and ritonavir.
• This product is used with other HIV medications to help control HIV infection.
• It helps to decrease the amount of HIV in your body so your immune system can work better.
• This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life.

Low-dose Dexamethasone

• It is a type of steroid, which is used in a range of conditions typically to reduce inflammation.

Convalescent plasma – blood

• Using people who have recovered that contains antibodies against the virus.

Risk in the Trial

• The officials of the trials believed:
• Apart from the known side effects of these treatments (which may include stomach upset, ‘flu-like symptoms, and blood test abnormalities), there is the unlikely possibility of a severe reaction to a study drug

Results of the trial

• The Recovery team expects to be the first to have definitive data.
• Prof Horby professor of emerging infectious diseases and global health at Oxford University, who is leading the trial said “We’re guessing some time in June we may get the results,”
• Please don’t use any of these medicines without the permission of the doctor All treatments are being done under the supervision of doctors.

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